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. 2020 May 20;11:704. doi: 10.3389/fphar.2020.00704

Figure 2.

Figure 2

Carvacrol and cinnamaldehyde robustly activate K2P5.1. (A) Activation of K2P5.1 by monoterpenes. Oocyte membrane potential was held at −80mV and pulsed to +25 mV for 75 ms with 5 s interpulse intervals. All MTs were applied at the same concentration (0.3 mM), and currents were measured after 5 min of incubation (mean ± S.E., n = 6–10). (B) Time course for activation by 0.3 mM carvacrol and 0.3 mM cinnamaldehyde for representative oocytes expressing K2P5.1 channels. Currents were measured as in (A). (C) Carvacrol dose-response for K2P5.1 channels (mean ± S.E., n = 5–8) (EC50 = 0.13 ± 0.05 mM). (D) Cinnamaldehyde dose–response for K2P5.1 channels (mean ± S.E., n = 5–8) (EC50 = 0.11 ± 0.07 mM). Currents were measured at 25 mV, as in (A), after incubation for 5 min. *p ≤ 0.05, **p ≤ 0.01.