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. 2020 May 20;11:704. doi: 10.3389/fphar.2020.00704

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Copyright © 2020 Arazi, Blecher and Zilberberg

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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K_2P17.1 and K_2P18.1 are activated by monoterpenes. (A), (B) Activation of K_2P17.1 (A) and K_2P18.1 (B) by monoterpenes. Oocyte membrane potential was held at −80 mV and pulsed to +25 mV for 75 ms with 5 s interpulse intervals. All MTs were applied at the concentration of 0.3 mM, and currents were measured 4 min after application of the indicated monoterpene (mean ± S.E., n = 5–10). Insets: currents of representative oocytes expressing K_2P17.1 (A) and K_2P18.1 (B) during application of 0.3 mM carvacrol. (C) Fraction of voltage-dependent (VD) current (in %) under control conditions and after application of 0.3 mM carvacrol for three channel types, as indicated. Oocytes were held at −80mV, and currents were measured at 30 mV. A fit of the results to an exponential decay slope was used to identify the initial current (mean ± S.E., n = 6–9). *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, ns, not significant.