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. 2020 May 20;11:704. doi: 10.3389/fphar.2020.00704

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Copyright © 2020 Arazi, Blecher and Zilberberg

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effect of monoterpenes on acid-sensitive K_2P channels. (A) Inhibition of K_2P3,1 and K_2P9.1 currents. Currents were measured before and after 2 in incubation with the indicated MT (mean ± S.E., n = 5–10). All MTs were applied at a concentration of 0.3 mM. (B) Normalized currents during 0.3 mM thymol application for representative oocytes expressing either K_2P2.1, K_2P3.1, and K_2P9.1. (C) The time constant (τ) of current changes during the application of thymol at different concentrations for K_2P2.1 or K_2P3.1 (mean ± S.E., n = 6–10). *p ≤ 0.05.