FIGURE 2.

Selected, bona fide LRRK2 interacting partners as found in the IntAct database. Top bona fide LRRK2 interactors have been grouped in different categories depending on the processes they play a role in, groups are highlighted with gray round boxes and titled accordingly. Known LRRK2 interactors that did not meet the MIscore ≥ 0.6 threshold are represented as rounded squares and those that are missing from Intact are represented as gray squares. Both have been located in the figure next to the broad categories defined for top bona fide LRRK2 interactors. Edges connecting lower confidence LRRK2 interactors to LRRK2/Lrrk2 have been omitted for the sake of clarity. Edges represented as dashed lines identify interactions for which there is experimental evidence for direct binding. For the rest of the visual features, please refer to in-figure legend and figure 1 legend. An interactive and downloadable version of this network can be found at http://ndexbio.org/#/network/5a2bb7fe-53fc-11ea-bfdc-0ac135e8bacf.