Figure 3.

Topical application of SAAP-148 ointment eradicates acute and established infections of MRSA and A. baumannii from the skin. Use of an ex vivo human skin ALI model to demonstrate that topical application of peptide SAAP-148 ointment eradicates acute (A) and established (C) infections of methicillin resistant Staphylococcus aureus (MRSA) and Acinetobacter baumannii infections from the skin within 4 h of treatment. Results are expressed as the numbers of viable bacteria (in log₁₀ CFU) per skin model of three to six donors. Each circle represents one skin sample, and bars indicate medians. *Significantly different (*P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001) as compared to the vehicle, as calculated using the Mann-Whitney rank sum test. (B) shows that these organisms form biofilms on the skin surface 24 h after inoculation. These results were excerpted from de Breij et al. (2018), with permission from AAAS.