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. 2020 May 26;10:8705. doi: 10.1038/s41598-020-65633-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MAP’s performance in predicting miRNA disease associations for four cancers, evaluated using experimental miRNA-disease associations from the dbDEMC database. For each cancer, four ROC curves are shown: (1) MAP, (2) CNMDA, a current state of the art method for miRNA-disease association prediction, (3) MDHGI, another current method for miRNA-disease association prediction, and (4) a randomized network generated from node label shuffling, as a negative control.