Table 1.

The relationship between inflammasome and EMT.

Year	Title	Authors	Main finds	Journal	References
2006	Role of caspases on cell death, inflammation, and cell cycle in glycerol-induced acute renal failure	Homsi, E.; Janino, P.; DE Faria, J. B.	Expression of IL-1β and IL-18 in epithelial tubular cells.	Kidney International	(151)
2009	TGF-beta1 induced epithelial to mesenchymal transition (EMT) in human bronchial epithelial cells is enhanced by IL-1beta but not abrogated by corticosteroids	Doerner, A. M.; Zuraw, B. L.	IL-1β can enhance TGF-β action and consequently, leads to EMT.	Respiratory Research	(160)
2010	Quantitative expression of RIG-like helicase, NOD-like receptor and inflammasome-related mRNAs in humans and mice	Lech, M.; Avila-Ferrufino, A.; Skuginna, V.; Susanti, H. E. et al.	Expression of inflammasome-related genes in epithelium of some organs such as kindney and spleen.	International Immunology	(150)
2013	Inflammasome-independent NLRP3 augments TGF-β signaling in kidney epithelium	Wang, W.; Wang, X.; Chun, J.; Vilaysane, A. et al.	EMT is trigger independently of the inflammasome oligomerization, just recquiring the presence of the NLRP3 receptor protein.	Journal of Immunolgy	(152)
2014	Renoprotective effect of paricalcitol via a modulation of the TLR4-NF-κB pathway in ischemia/reperfusion-induced acute kidney injury.	Lee, J. W.; Kim, S. C.; Ko, Y. S.; Lee, H. Y. et al.	Paricalcitol promotes a decrease on the the nuclear translocation of p65 subunit of NF-κB, which leads to a less expression of inflammasome-related genes.	Biochemical and Biophysical Research Communications	(155)
2016	Inflammasome-independent NLRP3 is required for epithelial-mesenchymal transition in colon cancer cells.	Wang, H.; Wang, Y.; Du, Q.; Lu, P. et al.	NLRP3 expression, but not the NLRP3 inflammasome complex activation, was required for EMT in colorectal cancer cells.	Experimental Cell Research	(153)
2016	Angiotensin(1-7) attenuated Angiotensin II-induced hepatocyte EMT by inhibiting NOX-derived H2O2-activated NLRP3 inflammasome/IL-1β/Smad circuit	Zhang, L. L.; Huang, S.; Ma, X. X.; Zhang, W. Y. et al.	NLRP3 inflammasome and Smad crosstalk to lead to EMT in renal fibrosis context.	Free Radical Biology and Medicine	(157)
2017	Structure Activity Relationships of Engineered Nanomaterials in inducing NLRP3 Inflammasome Activation and Chronic Lung Fibrosis	Wang, X.; Sun, B.; Liu, S.; Xia, T.	Nanomaterials induce NLRP3 activation and enhance, therefore the lung fibrosis.	NanoImpact	(158)
2017	NLRP3 participates in the regulation of EMT in bleomycin-induced pulmonary fibrosis.	Tian, R.; Zhu, Y.; Yao, J.; Meng, X. et al.	NLRP3 inflammasome leads to EMT via TGF-β, and once NLRP3 is silenced there are reduced TGF-β levels and thus EMT does not occur.	Experimental Cell Research	(38)
2017	Uric acid activates NRLP3 inflammasome in an in-vivo model of epithelial to mesenchymal transition in the kidney.	Romero, C. A.; Remor, A.; Latini, A.; De Paul, A. L. et al.	There is a co-localization between NLRP3 and Smad, besides, they showed an expression of all inflammasome proteins expression, suggesting an oligomerization leading to fibrosis.	Journal of Molecular Histology	(161)
2018	Knockdown of NLRP3 alleviates high glucose or TGFB1-induced EMT in human renal tubular cells.	Song, S.; Qiu, D.; Luo, F.; Wei, J. et al.	NLRP3 knockdown downregulates the expression of TGF-β1 and blocks the EMT process in high glucose-induced renal fibrosis.	Journal of Molecular Endocrinology	(162)
2019	Huangkui capsule alleviates renal tubular epithelial-mesenchymal transition in diabetic nephropathy via inhibiting NLRP3 inflammasome activation and TLR4/NF-κB signaling	Han, W.; Ma, Q.; Liu, Y.; Wu, W. et al.	Huangkui reduces the expression of the NLRP3 through the decrease into the TLR4/NF-κB protein levels.	Phytomedicine	(154)
2019	Paricalcitol attenuates TGF-β1-induced phenotype transition of human peritoneal mesothelial cells (HPMCs) via modulation of oxidative stress and NLRP3 inflammasome	Ko, J.; Kang, H. J.; Kim, D. A.; Ryu, E. S. et al.	Paricalcitol shows a reduction of the nlrp3 transcription.	The FASEB Journal	(156)