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. 2020 Jan 8;33:101426. doi: 10.1016/j.redox.2020.101426

Fig. 2.

Fig. 2

Schematic of mitochondrial quality control in fibrotic macrophages. (A) Fibrotic lung macrophages show increased mtROS mediated by Cu,Zn-SOD and MCU. Enhanced mtROS polarized macrophages to a profibrotic phenotype via Jmjd3 in a redox-dependent manner. (B) The increased mitophagy seen in fibrotic lung macrophages increases TGF-β1 secretion and leads to apoptosis resistance. (C) Increased mitochondrial biogenesis in fibrotic lung macrophages is induced via upregulation of PGC-1α and increased ATP production. Abbreviations: Jmjd3 = Jumonji domain containing 3; MCU = mitochondrial calcium uniporter; PARK2 = E3 ubiquitin-protein ligase parkin; TFAM = mitochondrial transcription factor A; TGF-β1 = transforming growth factor β1; SOD = superoxide dismutase.