Fig. 4.

(A) The geographical distribution of high confidence PZA drug resistance mutations. (B) Distance-based grouping of the mutations, using the PZA COM as origin. Mutation positions are represented as spheres, where Group 1 residues (≤6.7 Å) are coloured green, Group 2 residues (6.7 Å < X ≤ 11.0 Å) are coloured orange and Group 3 residues (>11.0 Å) are in blue. Group 4 mutations that coordinate the Fe²⁺ cofactor in the MBS are in black. The Fe²⁺-coordinating water molecules (HOH220 and HOH221) are depicted as sticks. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)