Fig. 14.

(A) A heat map showing the change in local residue fluctuations between the WT and mutants in PZA-bound systems exhibiting PZA release. Change in RMSF was calculated by subtracting the RMSF of each mutant PZA complex from the WT PZA-bound system. A negative change (red) indicates highly flexible regions as a result of mutation while positive change (blue) represents flexible regions in the WT. Heat map was plotted using the JupyterLab tool. (B) The raw RMSF values of WT PZA-bound complex. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)