Table 3.
Estimated exit time points for the initially PZA-bound protein complexes.
| Mutant | Estimated exit time (ns) | Group | Mutant | Estimated exit time (ns) | Group |
|---|---|---|---|---|---|
| A134V (test) | 48.71 | 1 | T61P (test) | 48.66 | 3 |
| V7G (test) | 148.41 | 2 | L85P (reference) | 61.83 | 3 |
| D8G (reference) | 18.26 | 2 | K96N (test) | 53.17 | 3 |
| V9A (test) | 85.65 | 2 | A146V (reference) | 7.34 | 3 |
| D12A (test) | 61.01 | 2 | L159P (reference) | 137.60 | 3 |
| W68R (test) | 126.62 | 2 | T160P (test) | 112.49 | 3 |
| Y103S (test) | 27.70 | 2 | D49A (reference) | 12.31 | 4 |
| V139M (reference) | 25.94 | 2 | D49G (reference) | 12.16 | 4 |
| A161P (reference) | 68.48 | 2 | H51P (test) | 29.80 | 4 |
| A3P (reference) | 33.80 | 3 | H57P (reference) | 23.95 | 4 |
| L35R (test) | 51.72 | 3 | H57Y (test) | 107.16 | 4 |
| H43P (test) | 74.51 | 3 | H71R (test) | 62.81 | 4 |
| L116R (test) | 26.59 | 3 |