. 2020 May 27;151:105386. doi: 10.1016/j.ejps.2020.105386

Table 4.

Human and environmental toxicological parameters predicted for benzothiazole 12

HUMAN TOXICITY
MaxRTD^a	Plipidosis^b	Developmental and genetic toxicity		Human liver adverse effects
		Repro_Tox^c	Mutagenesis^d	AlkPhos^e	GGT^f	LDH^g	AST^h	ALTⁱ
3.16	Nontoxic	Nontoxic	Negative	Normal	Normal	Normal	Elevated	Elevated
96%	99%	69%	99%	65%	97%	74%	85%	86%
ECOTOXICITY
Bioconcn^j	Biodegradn^k	Daphnia_LC₅₀^l	Minnow_LC₅₀^m	Estrogenic^m
68.75	No (95%)	0.11	7.53	Nontoxic (98%)

ⁿ Fathead minnow (Pimephales promelas) toxicity

MaxRTD (mg/kg/day): qualitative assessment of the Maximum Recommended Therapeutic Dose administered as an oral dose.

Plipidosis: qualitative estimation of potential for causing phospholipidosis.

Repro_Tox: qualitative estimation of reproductive / developmental toxicity, (confidence %).

Mutagenesis: classification model for the mutagenicity of pure compounds in S. typhimurium strain TA102 or E. coli strain WP2 uvrA, (confidence%).

AlkPhos: human liver adverse effect as the likelihood of causing elevation in the levels of Alkaline Phosphatase enzyme, (confidence %).

GGT: human liver adverse effect as the likelihood of causing elevation in the levels of gamma-glutamyl transferase (GGT) enzyme, (confidence %).

LDH: human liver adverse effect as the likelihood of causing elevation in the levels of lactate dehydrogenase (LDH) enzyme, (confidence %).

AST: human liver adverse effect as the likelihood of causing elevation in the levels of serum glutamic oxaloacetic transaminase (SGOT) enzyme, (confidence %).

ⁱ

ALT: human liver adverse effect as the likelihood of causing elevation in the levels of serum glutamic pyruvic transaminase (SGTP) enzyme, (confidence %).

Bioconcn (Cfish/Cwater): bioconcentration factor - partition coefficient between fish tissues and environmental water at steady state.

Biodegradn: likelihood of biodegradation in the environment expressed as relative biological oxygen demand.

Daphnia_LC₅₀ (mg/L): LC₅₀ for Daphnia magna (water flea) lethal toxicity after 48 hours of exposure.

Estrogenic: classification model for predicting antiestrogen activity in rats (confidence %).