Fig 3.

Incidence of ipsilateral invasive breast cancer according to various factors in 24 779 women diagnosed as having unilateral ductal carcinoma in situ (DCIS) as a result of screening during April 2000 to March 2014 and who had surgery. Women with oestrogen receptor positive DCIS and recorded as receiving endocrine treatment were excluded. For each factor, rates are shown relative to the first category shown and adjustment is for all other factors except final margin distance. Final margin distance was not included in adjustment as information on this variable was available only from 2007 onwards. Separate results for “breast conserving surgery with radiotherapy,” for “breast conserving surgery, radiotherapy not recorded,” and for “mastectomy” and results showing final margin distances of 1 mm and 2 mm separately are given in supplementary figures S1 to S3. BCS+RT=breast conserving surgery, radiotherapy recorded; BCS-RT: breast conserving surgery, radiotherapy not recorded. *Tests for trend excluding years 0.5-2.9: crude P=0.40; adjusted P=0.87. †Tests for trend across clear margin categories: crude P=0.001; adjusted P=0.009