Table 1.
Characteristics of 35 024 women in England diagnosed as having ductal carcinoma in situ (DCIS) as a result of screening between January 1988 and March 2014, and their status on 31 December 2014. Values are numbers (percentages)
| Screened before April 2000 (n=4465) | Screened April 2000 to March 2014 | Total (n=35 024) | ||||||
|---|---|---|---|---|---|---|---|---|
| Bilateral DCIS (n=63) | Unilateral DCIS | |||||||
| BCS+RT (n=5368) | BCS-RT (n=15 188) | Mastectomy (n=8488) | No surgery recorded (n=1452) | |||||
| Year of screening | ||||||||
| Before April 2000 | 4465 (100.0) | — | — | — | — | — | 4465 (12.7) | |
| April 2000-Dec 2004 | — | 14 (22) | 669 (12.5) | 3617 (23.8) | 1985 (23.4) | 557 (38.4) | 6842 (19.5) | |
| Jan 2005-Dec 2009 | — | 23 (37) | 1313 (24.5) | 5908 (38.9) | 3203 (37.7) | 320 (22.0) | 10 767 (30.7) | |
| Jan 2010-March 2014 | — | 26 (41) | 3386 (63.1) | 5663 (37.3) | 3300 (38.9) | 575 (39.6) | 12 950 (37.0) | |
| Age at DCIS diagnosis, years | ||||||||
| <55 | 1630 (36.5) | 19 (30) | 1611 (30.0) | 4577 (30.1) | 2829 (33.3) | 459 (31.6) | 11 125 (31.8) | |
| 55-59 | 1234 (27.6) | 16 (25) | 1122 (20.9) | 3107 (20.5) | 1820 (21.4) | 304 (20.9) | 7603 (21.7) | |
| 60-64 | 1234 (27.6) | 10 (16) | 1183 (22.0) | 3446 (22.7) | 1789 (21.1) | 329 (22.7) | 7991 (22.8) | |
| ≥65 | 367 (8.2) | 18 (29) | 1452 (27.0) | 4058 (26.7) | 2050 (24.2) | 360 (24.8) | 8305 (23.7) | |
| Region | ||||||||
| Eastern | — | 6 (10) | 1367 (25.5) | 1315 (8.7) | 978 (11.5) | 118 (8.1) | 3784 (10.8) | |
| North West | — | 5 (8) | 456 (8.5) | 2117 (13.9) | 1105 (13.0) | 119 (8.2) | 3802 (10.9) | |
| Northern/Yorkshire | — | 9 (14) | 1758 (32.7) | 1176 (7.7) | 1433 (16.9) | 88 (6.1) | 4464 (12.7) | |
| Oxford | — | 5 (8) | 161 (3.0) | 1052 (6.9) | 450 (5.3) | 38 (2.6) | 1706 (4.9) | |
| South West | — | 10 (16) | 216 (4.0) | 3162 (20.8) | 1327 (15.6) | 108 (7.4) | 4823 (13.8) | |
| Thames | — | 15 (24) | 607 (11.3) | 3472 (22.9) | 1600 (18.9) | 396 (27.3) | 6090 (17.4) | |
| Trent | — | 5 (8) | 413 (7.7) | 1242 (8.2) | 824 (9.7) | 532 (36.6) | 3016 (8.6) | |
| West Midlands | — | 8 (13) | 390 (7.3) | 1652 (10.9) | 771 (9.1) | 53 (3.7) | 2874 (8.2) | |
| Unknown | 4465 (100.0) | — | — | — | — | — | 4465 (12.7) | |
| Tumour size, mm | ||||||||
| ≤10 | — | 14 (22) | 1595 (29.7) | 7085 (46.6) | 853 (10.0) | 390 (26.9) | 9937 (28.4) | |
| 11-20 | — | 14 (22) | 2147 (40.0) | 4820 (31.7) | 1687 (19.9) | 352 (24.2) | 9020 (25.8) | |
| 21-50 | — | 18 (29) | 1551 (28.9) | 3056 (20.1) | 4034 (47.5) | 309 (21.3) | 8968 (25.6) | |
| ≥51 | — | 9 (14) | 75 (1.4) | 227 (1.5) | 1914 (22.5) | 56 (3.9) | 2281 (6.5) | |
| Unknown | 4465 (100.0) | 8 (13) | — | — | — | 345 (23.8) | 4818 (13.8) | |
| DCIS grade | ||||||||
| Low/intermediate | — | 23 (37) | 1375 (25.6) | 8019 (52.8) | 2337 (27.5) | 535 (36.8) | 12 289 (35.1) | |
| High | — | 33 (52) | 3993 (74.4) | 7169 (47.2) | 6151 (72.5) | 680 (46.8) | 18 026 (51.5) | |
| Unknown | 4465 (100.0) | 7 (11) | — | — | — | 237 (16.3) | 4709 (13.4) | |
| Oestrogen receptor status and endocrine treatment | ||||||||
| ER+, no endocrine | — | 21 (33) | 3585 (66.8) | 9947 (65.5) | 5003 (58.9) | 277 (19.1) | 18 833 (53.8) | |
| ER+, endocrine | — | 10 (16) | 569 (10.6) | 2747 (18.1) | 950 (11.2) | 245 (16.9) | 4521 (12.9) | |
| ER- | — | 7 (11) | 1214 (22.6) | 2494 (16.4) | 2535 (29.9) | 127 (8.7) | 6377 (18.2) | |
| Unknown | 4465 (100.0) | 25 (40) | — | — | — | 803 (55.3) | 5293 (15.1) | |
| Laterality of DCIS | ||||||||
| Left | 2230 (49.9) | — | 2802 (52.2) | 7821 (51.5) | 4365 (51.4) | 748 (51.5) | 17 966 (51.3) | |
| Right | 2049 (45.9) | — | 2566 (47.8) | 7367 (48.5) | 4123 (48.6) | 691 (47.6) | 16 796 (48.0) | |
| Bilateral | 13 (0.3) | 63 (100) | — | — | — | — | 76 (0.2) | |
| Unknown | 173 (3.9) | — | — | — | — | 13 (0.9) | 186 (0.5) | |
| Length of follow-up, years | ||||||||
| 0-4 | 162 (3.6) | 27 (43) | 3428 (63.9) | 5939 (39.1) | 3441 (40.5) | 609 (41.9) | 13 606 (38.8) | |
| 5-9 | 219 (4.9) | 23 (37) | 1316 (24.5) | 5898 (38.8) | 3214 (37.9) | 328 (22.6) | 10 998 (31.4) | |
| 10-14 | 525 (11.8) | 13 (21) | 624 (11.6) | 3351 (22.1) | 1833 (21.6) | 515 (35.5) | 6861 (19.6) | |
| 15-19 | 2620 (58.7) | — | — | — | — | — | 2620 (7.5) | |
| ≥20 | 939 (21.0) | — | — | — | — | — | 939 (2.7) | |
| Invasive breast cancer diagnosed by 31 Dec 2014 | ||||||||
| Ipsilateral | 320 (7.2) | — | 73 (1.4) | 460 (3.0) | 113 (1.3) | 63 (4.3) | 1029 (2.9) | |
| Contralateral | 234 (5.2) | — | 84 (1.6) | 297 (2.0) | 206 (2.4) | 39 (2.7) | 860 (2.5) | |
| Laterality unknown | 89 (2.0) | 5 (8) | 7 (0.1) | 41 (0.3) | 35 (0.4) | 10 (0.7) | 187 (0.5) | |
| Vital status on 31 Dec 2014 | ||||||||
| Alive | 3363 (75.3) | 60 (95) | 5220 (97.2) | 14 472 (95.3) | 8103 (95.5) | 1345 (92.6) | 32 563 (93.0) | |
| Emigrated | 151 (3.4) | — | 6 (0.1) | 46 (0.3) | 22 (0.3) | 2 (0.1) | 227 (0.6) | |
| Dead | 951 (21.3) | 3 (5) | 142 (2.6) | 670 (4.4) | 363 (4.3) | 105 (7.2) | 2234 (6.4) | |
| Cause of death | ||||||||
| Breast cancer | 150 | 1 | 16 | 67 | 53 | 23 | 310 | |
| Other known causes | 725 | 2 | 126 | 595 | 300 | 79 | 1827 | |
| Unknown cause | 76 | 0 | 0 | 8 | 10 | 3 | 97 | |
BCS+RT=breast conserving surgery, radiotherapy recorded; BCS-RT=breast conserving surgery, radiotherapy not recorded; ER+, no endocrine=oestrogen receptor positive DCIS, endocrine therapy not recorded; ER+, endocrine=oestrogen receptor positive DCIS, endocrine therapy recorded; ER-=oestrogen receptor negative DCIS.