Table 2. Maximum Transverse Diameter and Volume of Abdominal Aortic Aneurysms by Treatment Assignment.
Doxycycline (n = 129) |
Placebo (n = 125) |
Difference (95% CI) | P valuea | |
---|---|---|---|---|
Full analysis population | ||||
Maximum transverse diameter, cm | ||||
6 mo, No. of patients | 119 | 116 | ||
Mean (SD) | 4.40 (0.44) | 4.40 (0.43) | 0 (−0.12 to 0.11) | .94 |
1 y, No. of patients | 119 | 113 | ||
Mean (SD) | 4.49 (0.48) | 4.48 (0.44) | 0.02 (−0.10 to 0.13) | .80 |
2 y, No. of patients | 96 | 101 | ||
Mean (SD) | 4.61 (0.52) | 4.61 (0.53) | 0 (−0.15 to 0.15) | .99 |
Baseline to 2-y change | ||||
No. of patients b | 96 | 101 | ||
Mean (SD) | 0.36 (0.21) | 0.36 (0.28) | 0 (−0.07 to 0.07) | .93 |
Volume, cm3 | ||||
6 mo, No. of patients | 119 | 116 | ||
Mean (SD) | 102.90 (26.19) | 100.40 (26.27) | 2.52 (−4.22 to 9.26) | .46 |
1 y, No. of patients | 119 | 113 | ||
Mean (SD) | 106.00 (29.13) | 105.00 (28.28) | 0.95 (−6.48 to 8.38) | .80 |
2 y, No. of patients | 96 | 101 | ||
Mean (SD) | 113.60 (34.91) | 111.20 (33.14) | 2.41 (−7.16 to 11.97) | .62 |
Baseline to 2-y change | ||||
No. of patientsb | 96 | 101 | ||
Mean (SD) | 18.60 (14.38) | 19.16 (15.75) | −0.56 (−4.81 to 3.68) | .79 |
Per-protocol population | ||||
Maximum transverse diameter, cm | ||||
6 mo, No. of patients | 64 | 71 | ||
Mean (SD) | 4.35 (0.47) | 4.42 (0.41) | −0.07 (−0.21 to 0.08) | .38 |
1 y, No. of patients | 66 | 72 | ||
Mean (SD) | 4.44 (0.49) | 4.51 (0.42) | −0.07 (−0.23 to 0.08) | .35 |
2 y, No. of patients | 61 | 67 | ||
Mean (SD) | 4.54 (0.55) | 4.66 (0.50) | −0.12 (−0.30 to 0.06) | .21 |
2-y to Baseline, No. of patients b | 61 | 67 | ||
Mean (SD) | 0.33 (0.22) | 0.36 (0.26) | −0.03 (−0.12 to 0.05) | .47 |
Volume, cm3 | ||||
6 mo, No. of patients | 64 | 71 | ||
Mean (SD) | 96.70 (25.95) | 101.60 (23.48) | −4.89 (−13.31 to 3.52) | .25 |
1 y, No. of patients | 66 | 72 | ||
Mean (SD) | 100.70 (28.79) | 105.60 (25.64) | −4.93 (−14.10 to 4.23) | .29 |
2 y, No. of patients | 61 | 67 | ||
Mean (SD) | 106.80 (35.67) | 114.00 (31.98) | −7.22 (−19.06 to 4.61) | .23 |
2-y to Baseline, No. of patients b | 61 | 67 | ||
Mean (SD) | 15.78 (13.95) | 19.16 (16.18) | 3.38 (−8.69 to 1.93) | .21 |
Two-sample t test P values.
Mean changes in measured maximum transverse diameter and volume based on patients for whom computed tomographic scans were available.