Table 3.
Osteoclast parameters and the erosive progression in RA.
| Erosion SHS < 5 at V4 |
Erosion SHS ≥ 5 at V4 |
p | p-adj⁎ | |||
|---|---|---|---|---|---|---|
| n | median (IQR) | n | median (IQR) | |||
| All | n = 16 | n = 82 | ||||
| OCs/well V1 | 16 | 286.5 (210.0–744.5) | 82 | 372.5 (153.0–668.0) | 0.5446 | 0.5307 |
| CD14% PBMCs V1 | 16 | 15.0 (9.9–19.6) | 82 | 17.4 (12.6–23.7) | 0.1440 | 0.2792 |
| Resorption (μm2) V1 | 15 | 82,484 (0–1,264,508) | 82 | 0 (0–836,372) | 0.3865 | 0.7158 |
| Apoptosis (%) V1 | 13 | 17.0 (12.0–18.0) | 58 | 7.5 (4.0–15.0) | 0.1081 | 0.2531 |
| RA > 5 years | ||||||
| OCs/well V1 | 5 | 592.0 (306.0–783.0) | 64 | 334.5 (124.0–682.5) | 0.2467 | 0.4193 |
| CD14% PBMCs V1 | 5 | 19.1 (12.3–21.6) | 64 | 17.3 (12.5–23.7) | 0.9631 | 0.8562 |
| Resorption (μm2) V1 | 4 | 85,782 (33411–684,625) | 64 | 0 (0–404,559) | 0.5374 | 0.6845 |
| Apoptosis (%) V1 | 4 | 0.0 (0.0–8.5) | 44 | 8.0 (4.5–16.5) | 0.1144 | 0.1957 |
| RA ≤ 5 years | ||||||
| OCs/well V1 | 11 | 258.0 (191.0–706.0) | 18 | 487.0 (229.0–535.0) | 0.6691 | 0.9243 |
| CD14% PBMCs V1 | 11 | 14.9 (7.7–18.6) | 18 | 17.8 (12.9–25.9) | 0.1265 | 0.1817 |
| Resorption (μm2) V1 | 11 | 82,484 (0–2,733,971) | 18 | 482,357 (0–1,410,990) | 0.7816 | 0.9137 |
| Apoptosis (%) V1 | 9 | 18.0 (17.0–21.0) | 14 | 5.0 (3.0–12.0) | 0.0036 | 0.0287 |
IQR: Interquartile Range (25th–75th percentiles).
Erosion SHS: Erosion score from the Sharp/van der Heijde modified method; OC: osteoclast.
⁎
p adjusted for DAS28.