Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Schematic of the interaction of BChE and a model OP toxicant (paraoxon). First, an OP compound and BChE form a reversible Michaelis-complex (k1/k−1), however the bond quickly progresses through this step to phosphylation at a rate of k2. Spontaneous reactivation (k3) does not occur at an appreciable rate in the wild-type enzyme, but is detectable in the mutant BChEG117H16.
