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. 2020 Apr 22;44(1):156–164. doi: 10.3892/or.2020.7592

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Copyright: © Sun et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — The forced expression of Cav2.1 mt and Cav2.1dm3 induces cell apoptosis in SH-SY5Y cells. (A) The flow cytometric result indicated that compared with the Cav2.1 wt and EV groups, the forced expression of Cav2.1 mt and Cav2.1dm3 significantly induced cell apoptosis in SH-SY5Y cells. **P<0.01, a significant difference in cell apoptosis was observed between EV/Cav2.1 wt and Cav2.1 mt/Cav2.1dm3, and Cav2.1 mt and Cav2.1dm3. NS, no difference in cell apoptosis was observed between EV and Cav2.1 wt (Tukey's test). (B) Cell morphology also revealed that Cav2.1 mt and Cav2.1dm3 markedly induced cell apoptosis. Cav2.1 mt, mutant-type Cav2.1; Cav.1 wt, wild-type Cav2.1; EV, empty vector; NS, no significance.

Figure 4. — The forced expression of Cav2.1 mt and Cav2.1dm3 induces cell apoptosis in SH-SY5Y cells. (A) The flow cytometric result indicated that compared with the Cav2.1 wt and EV groups, the forced expression of Cav2.1 mt and Cav2.1dm3 significantly induced cell apoptosis in SH-SY5Y cells. **P<0.01, a significant difference in cell apoptosis was observed between EV/Cav2.1 wt and Cav2.1 mt/Cav2.1dm3, and Cav2.1 mt and Cav2.1dm3. NS, no difference in cell apoptosis was observed between EV and Cav2.1 wt (Tukey's test). (B) Cell morphology also revealed that Cav2.1 mt and Cav2.1dm3 markedly induced cell apoptosis. Cav2.1 mt, mutant-type Cav2.1; Cav.1 wt, wild-type Cav2.1; EV, empty vector; NS, no significance.