Table II.
Univariate and multivariate analyses of prognostic factor for overall survival in 77 pancreatic cancer patients.
| Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
| Clinicopathological factors | HR | 95% CI | P-valuea | HR | 95% CI | P-valuea |
| Age(years) | ||||||
| (≦71 vs. >71) | 1.03 | 0.54–1.92 | 0.9214 | – | – | – |
| Sex | ||||||
| (male vs. female) | 0.57 | 0.30–1.06 | 0.076 | – | – | – |
| TNM stage UICC 7th | ||||||
| (IIA vs. IIB) | 0.59 | 0.26–1.21 | 0.1575 | – | – | – |
| Tumor location | ||||||
| (body/tail vs. head) | 0.65 | 0.33–1.22 | 0.1861 | – | – | – |
| Histological differentiation | ||||||
| (G1 vs. G2, G3, G4) | 0.34 | 0.16–0.66 | 0.0012b | 0.26 | 0.11–0.56 | 0.0004b |
| Lymphatic invasion | ||||||
| (ly0, ly1 vs. ly2, ly3) | 0.71 | 0.37–1.31 | 0.2754 | – | – | – |
| Venous invasion | ||||||
| (v0, v1 vs. v2, v3) | 0.94 | 0.35–2.09 | 0.8849 | – | – | – |
| Perineural invasion | ||||||
| (ne0, ne1 vs. ne2, ne3) | 0.62 | 0.27–1.29 | 0.2108 | – | – | – |
| Resection margin | ||||||
| (R0 vs. R1, R2) | 0.36 | 0.22–0.63 | 0.0004b | 0.28 | 0.14–0.56 | 0.0004b |
| Adjuvant chemotherapy | ||||||
| (present vs. absent) | 0.26 | 0.13–0.50 | <0.0001b | 0.34 | 0.17–0.71 | 0.0013b |
| pIgR | ||||||
| (low vs. high) | 0.56 | 0.27–0.97 | 0.0404b | 0.35 | 0.17–0.71 | 0.0045b |
a
Cox proportional hazard model.
b
Statistically significant. 95% CI, 95% confidence interval; pIgR, polymeric immunoglobulin receptor.