Fig. 5.

Reproductive decision tree for members of families with OI risk. Based on the OI inheritance pattern in the family, and the wishes of the prospective parents, a specific autonomous decision-supportive reproductive strategy could be chosen. AD – Autosomal Dominant; AR – Autosomal recessive; IVF – In Vitro Fertilisation; NIPT – Non-invasive Prenatal testing; OI – Osteogenesis Imperfecta; PCS – Preconception Carrier Screening; PGT-M – Preimplantation Genetic Testing for Monogenic Disease; XLR – X-linked recessive