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. 2020 May 27;11:203. doi: 10.1186/s13287-020-01702-x

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Retinal nerve fiber layer thickness (RNFL) 60 days post-treatment. a Immunostaining against Tuj1 as a neural marker. The nuclei were counterstained with DAPI. b The diameter of the Tuj1+ area revealed by immunostaining in (a). The vehicle group had a decreased retinal nerve fiber layer (RNFL) compared with the extracellular vesicle (EV) group. Data are presented as Violin plot for four optic nerves per group. The data were analyzed by the un-paired t test. ***P < 0.001. c Representative image of mice eye from dorsal view, enucleated 15 and 30 min post-injection of Calcein-labeled EVs via tail vein