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. 2020 Apr 21;44(1):213–223. doi: 10.3892/or.2020.7590

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Copyright: © Li et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — RAD18 promotes CRC cell invasion in vitro. The Matrigel Transwell assay was performed to determine cell invasion potential. The number of cells migrated to the bottom was calculated manually. RAD18 knockdown suppressed the cell invasion in HCT116 and DLD-1 cells, whereas overexpression of RAD18 enhanced the cell invasion of SW480 cells. (A-C) Representative images of invasive cells. (D-F) Quantification analysis of the invasive cell number per field. Data represent mean ± SD of duplicates from three fields of view. *P<0.05, **P<0.01, ***P<0.001, Student's t-test. RAD18sh, RAD18-knockdown cells; RAD18, RAD18-overexpressing cells. RAD18, E3 ubiquitin protein ligase; CRC, colorectal cancer.