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. 2020 Apr 21;44(1):213–223. doi: 10.3892/or.2020.7590

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Copyright: © Li et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 7. — The mutant RAD18 reverses the genetic phenotype of RAD18-knockdown cells. DLD-1 RAD18sh (RAD18 knockdown) cells were also transfected with the RAD18-encoding plasmid. (A and B) EMT biomarkers, including E-cadherin, N-cadherin, vimentin and RAD18 were detected by western blot analysis, and quantified (right panel). (C and D) Transwell assays and (E and F) wound-healing assays were performed to confirm the RAD18-mediated invasion and migration ability of DLD-1 cells, and the results were quantified and shown in histograms (right panels). **P<0.01, ***P<0.001, Newman-Keuls. EMT, epithelial-mesenchymal transition; RAD18, E3 ubiquitin protein ligase.