Table II.
Univariate and multivariate Cox regression analysis for OS in CRC patients.
| Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|
| Variates | Categories | HR (95% CI) | P-value | HR (95% CI) | P-value |
| Sex | Female vs. Male | 1.212 (0.706–2.081) | 0.485 | ||
| Age | >60 vs. ≤60 years | 1.504 (0.826–2.736) | 0.182 | 1,810 (0.954–3.435) | 0.069 |
| Differentiation | Poor vs. Well/Moderate | 1.904 (0.758–4.787) | 0.171 | 1.150 (0.433–3.053) | 0.779 |
| pT | T4 vs. T1-3 | 1.557 (0.899–2.697) | 0.114 | 1.489 (0.823–2.694) | 0.189 |
| pN | N1-3 vs. N0 | 2.782 (1.610–4.809) | <0.001b | 0.300 (0.061–1.463) | 0.136 |
| TNM stage | III–IV vs. II | 3.092 (1.776–5.383) | <0.001b | 9.067 (1.781–46.152) | 0.008b |
| MSH2 expression | High vs. Low | 0.635 (0.359–1.122) | 0.118 | 0.760 (0.412–1.402) | 0.760 |
| MSH6 expression | High vs. Low | 0.554 (0.220–1.392) | 0.209 | ||
| RAD18 expression | High vs. Low | 2.365 (1.361–4.110) | 0.002b | 1.809 (1.005–3.256) | 0.048a |
a
P<0.05
b
P<0.01; Fisher's exact test was performed. OS, overall survival; HR, hazard ratio; CI, confidence interval; p, pathological staging; TNM, Tumor-Node-Metastasis; MSH2, mutS homolog 2; MSH6, mutS homolog 6; RAD18, E3 ubiquitin protein ligase.