Table 1.
CK20, AMACR, and p53 staining in Intradepartmental Consensus Urothelial Lesions
| CK20 Proportion | CK20 Intensity | AMACR Proportion | AMACR Intensity | p53 Patterna | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N (%) | – | ± | + | 0+ | 1+ | 2+ | – | ± | + | 0+ | 1+ | 2+ | Wild type | Mutant | Equivocal | |
| Reactive | 15 | 13 (87) | 1 (7) | 1 (7) | 13 (87) | 1 (7) | 1 (7) | 15 (100) | 0 | 0 | 15 (100) | 0 | 0 | 12 (80) | 0 | 3 (20) |
| CIS | 15 | 1 (7) | 4 (27) | 10 (67) | 1 (7) | 4 (27) | 10 (67) | 3 (20) | 5 (33) | 7 (47) | 3 (20) | 8 (53%) | 4 (27) | 1 (7) | 9 (60) | 5 (33) |
Abbreviations: CK20 cytokeratin 20, AMACR alpha-methylacyl-CoA racemase;
Staining Proportion: -, negative; ±, patchy; +, diffuse
Staining Intensity: 0+ negative; 1+ weak; 2+ strong
a Please see Methods for description of scoring pattern