Table 1.
Clinical, laboratory, ultrasonographic, hepatobiliary scintigraphy characteristics of the derivation cohort
| Parameters | BA | Non-BA | Control | P | BA vs Non-BA |
|---|---|---|---|---|---|
| n = 34 | n = 32 | n = 37 | Pa | ||
| Baseline characters | |||||
| Maternal age (year) (Mean, SD) | 30 (4) | 26 (3) | 30 (4) | 0.437 | 0.272 |
| Birth weight (g) (Mean, SD) | 3232 (461) | 2931 (770) | 3393 (477) | 0.241 | 0.218 |
| Age at admission (day) (Mean, SD) | 51 (16) | 50 (13) | 42 (12) | 0.151 | 0.176 |
| Weight at admission (g) (Mean, SD) | 4514 (844) | 3951 (818) | 4264 (1014) | 0.306 | 0.096 |
| Parity (N, %) | 0.013 | 0.981 | |||
| 0 | 24 (70.6) | 23 (71.9) | 28 (75.7) | ||
| ≥ 1 | 10 (29.4) | 9 (28.1) | 9 (24.3) | ||
| Sex (N, %) | 0.117 | 0.051 | |||
| Male | 13 (38.2) | 20 (62.5) | 16 (43.2) | ||
| Female | 21 (61.8) | 12 (37.5) | 21 (56.8) | ||
| Clinical measures | |||||
| Recurrent jaundice (N, %) | 4 (11.8) | 9 (28.1) | / | / | 0.097 |
| Clay stool (N, %) | 23 (67.7) | 7 (21.9) | / | / | < 0.001 |
| Hepatomegaly (N, %) | 19 (55.9) | 9 (28.1) | / | / | 0.024 |
| Splenomegaly (N, %) | 7 (20.6) | 7 (21.9) | / | / | 0.899 |
| Liver function test (Median, IQR) | |||||
| Total bile acid (μmol/L) | 105 (73, 132) | 82 (68, 124.5) | 8 (6, 15) | < 0.001 | 0.141 |
| Alanine transaminase (U/L) | 111.5 (72, 235) | 118.5 (87.5, 184) | 40 (30, 50) | < 0.001 | 0.963 |
| Aspartate transaminase (U/L) | 219 (133, 308) | 170 (132.5, 296.5) | 50 (39, 61) | < 0.001 | 0.572 |
| Alkaline phosphatase (U/L) | 541.5 (446, 619) | 510.5 (373, 618.5) | 213 (171, 246) | < 0.001 | 0.959 |
| Total bilirubin (μmol/L) | 162.5 (143, 194) | 141.5 (101, 220.5) | 24 (16, 47) | < 0.001 | 0.047 |
| Direct bilirubin (μmol/L) | 107 (79, 124) | 96 (49, 131) | 0 (0, 0) | < 0.001 | 0.342 |
| Albumin (g/L) | 39 (35, 41) | 36 (34, 40) | 38 (34, 39) | 0.153 | 0.091 |
| γ-glutamyl transferase (U/L) | 440 (222, 731) | 117 (85, 273) | 67 (41, 94) | < 0.001 | < 0.001 |
| Ultrasonography findings | |||||
| Abnormal gallbladder (N, %) | 14 (41.2) | 3 (9.4) | / | / | 0.003 |
| Triangular cord sign (N, %) | 3 (8.8) | 2 (6.3) | / | / | 0.693 |
| Internal diameter of common hepatic duct(mm) (Median, IQR) | 1.2 (0.6, 1.5) | 1.3 (1.0, 1.4) | / | / | 0.712 |
| Positive finding in hepatobiliary scintigraphy (N, %) | 29 (85.3) | 14 (43.8) | / | / | < 0.001 |
BA Biliary atresia
a Variance analysis, Mann-Whitney test or Chisq test of BA and non-BA group