Table 2.
Bile acid assay of derivation cohort and normal controls
| BA (n = 34) | Non-BA (n = 32) | Control (n = 37) | Pa | |
|---|---|---|---|---|
| CA (ng/ml) | 9 (8, 13)c | 10.3 (8, 15)d | 97 (60, 172) | < 0.001 |
| CDCA (ng/ml) | 16 (1, 21) b, c | 26 (14, 37)d | 216 (108, 324) | < 0.001 |
| GDCA (ng/ml) | 5.2 (2.0, 7.2)c | 1.8 (2.0, 5.9) | 0.9 (0.5, 2.9) | < 0.001 |
| GCA (ng/ml) | 6160 (3476, 9978) b, c | 3044 (1274, 5920)d | 820 (428, 1824) | < 0.001 |
| GCDCA (ng/ml) | 11,440 (7800, 18,600)b, c | 5680 (3474, 10,960)d | 2527 (1768, 3980) | < 0.001 |
| TCA (ng/ml) | 7936 (4740, 12,245)c | 6080 (4080, 10,170)d | 574 (249, 1684) | < 0.001 |
| TCDCA (ng/ml) | 16,160 (8720, 23,908)c | 13,680 (8740, 19,600)d | 1633 (784, 3892) | < 0.001 |
| GCDCA/CDCA | 685 (394, 1288)b,c | 266 (100, 596)d | 13 (6, 20) | < 0.001 |
Data are presented as median (IQR)
a P value: data were analyzed using Kruskal-Wallis test
b Paired comparisons with significance (p < 0.017), using Mann-Whitney test between BA vs Non-BA
c Paired comparisons with significance (p < 0.017), using Mann-Whitney test between BA vs Control
d Paired comparisons with significance (p < 0.017), using Mann-Whitney test between Non-BA vs Control
CA Cholic acid; CDCA Chenodeoxycholic acid; GDCA Glycodeoxycholic acid; GCA Glycocholic acid; GCDCA Glycochenodeoxycholic acid; TCA Taurocholic acid; TCDCA taurochenodeoxycholic acid