Table II.
Univariate and multivariate Cox regression analysis of DJ-1 expression and clinicopathological variables predicting survival in CRC patients.
| N=470 cases | ||
|---|---|---|
| Variables | HR (95% CI) | P-value |
| Univariate Cox regression analysis | ||
| Age (≤65 vs. >65 years) | 1.607 (1.215–2.126) | 0.001 |
| Sex (male vs. female) | 1.013 (0.762–1.347) | 0.927 |
| Pathological classification (I/II vs. III) | 2.475 (1.587–3.860) | <0.001 |
| Depth of invasion (T1/T2 vs. T3/T4) | 3.687 (2.270–5.990) | <0.001 |
| Lymph node metastasis (N0 vs. N1/N2) | 2.807 (2.112–3.731) | <0.001 |
| TNM stage (I/II vs. III/IV) | 3.214 (2.407–4.291) | <0.001 |
| Distant metastasis (M0 vs. M1) | 8.150 (4.849–13.699) | <0.001 |
| Tumor diameter (≤5 cm vs. >5 cm) | 1.196 (0.848–1.688) | 0.307 |
| DJ-1 expression (low vs. high) | 0.255 (0.191–0.340) | <0.001 |
| Multivariate Cox regression analysisa | ||
| Sex (male vs. female) | 0.914 (0.684–1.222) | 0.544 |
| Pathological classification (I/II vs. III) | 2.301 (1.420–3.731) | 0.001 |
| TNM stage (I/II vs. III/IV) | 2.452 (1.810–3.324) | <0.001 |
| Tumor diameter (≤5 cm vs. >5 cm) | 0.978 (0.675–1.415) | 0.904 |
| DJ-1 expression (low vs. high) | 0.301 (0.224–0.405) | <0.001 |
a
Multivariate Cox regression analysis including sex, pathological classification, TNM stage, tumor diameter and DJ-1 expression. CRC, colorectal cancer; HR, hazard ratio; CI, confidence interval.