Figure 1.

NEAT1 expression is increased and miR-638 is decreased in the serum of AS cases and in ox-LDL-triggered HAECs. Expression levels of (A) NEAT1 and (B) miR-638 in the serum of 24 AS cases and 24 healthy controls. HAECs were treated with ox-LDL (0, 25, 50, and 75 µg/ml) for 1 day, and (C) NEAT1 and (D) miR-638 expression levels were examined. *P<0.05, **P<0.01 and ***P<0.001. NEAT1, nuclear paraspeckle assembly transcript 1; AS, atherosclerosis; HAECs, human aortic endothelial cells; ox-LDL, oxidized low-density lipoprotein.