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. 2020 May 7;44(1):115–125. doi: 10.3892/or.2020.7605

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — NEAT1 downregulation decreases cell proliferation and triggers the apoptosis of ox-LDL-induced HAECs. HAECs were subjected to si-NEAT1#1, si-NEAT1#2, or si-con transfection and ox-LDL (50 µg/ml) treatment for 1 day. Then, (A) NEAT1 expression, (B) proliferation potential, (C) colony formation ability, (D) PCNA and Ki-67 expression levels, (E) caspase-3 activity, (F) Bcl-2 and Bax expression levels and (G) cells undergoing apoptosis were detected. *P<0.05, **P<0.01 and ***P<0.001. NEAT1, nuclear paraspeckle assembly transcript 1; ox-LDL, oxidized low-density lipoprotein; HAECs, human aortic endothelial cells; PCNA, proliferating cell nuclear antigen.

Figure 2. — NEAT1 downregulation decreases cell proliferation and triggers the apoptosis of ox-LDL-induced HAECs. HAECs were subjected to si-NEAT1#1, si-NEAT1#2, or si-con transfection and ox-LDL (50 µg/ml) treatment for 1 day. Then, (A) NEAT1 expression, (B) proliferation potential, (C) colony formation ability, (D) PCNA and Ki-67 expression levels, (E) caspase-3 activity, (F) Bcl-2 and Bax expression levels and (G) cells undergoing apoptosis were detected. *P<0.05, **P<0.01 and ***P<0.001. NEAT1, nuclear paraspeckle assembly transcript 1; ox-LDL, oxidized low-density lipoprotein; HAECs, human aortic endothelial cells; PCNA, proliferating cell nuclear antigen.