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. 2019 Nov 21;26(4):294–300. doi: 10.1177/1753425919886643

Figure 1.

Figure 1.

Leptin promotes the differentiation of Th17 cells from MRL/lpr lupus mice. mRNA levels of (a) IL-17A, (b) IL-17F, and (c) RORγt by qPCR and (d) IL-17A and (e) IL-17F by ELISA in CD4+ T cells from MRL/lpr lupus mice stimulated under Th17 polarizing conditions and treated with leptin at scalar doses during the last 18 h of culture. Flow cytometry results of CD4+ IL-17+ from CD4+ T cells treated as above. (g) Representative and (F) cumulative data from two experiments (n = 10). *P < 0.05, **P < 0.01, ***P < 0.001.