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. 2019 Nov 21;26(4):294–300. doi: 10.1177/1753425919886643

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© The Author(s) 2019

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 3. — Inhibition of the NLRP3 inflammasome down-regulates the percentage of Th17 cells induced by leptin from MRL/lpr lupus mice. mRNA levels of (a) NLRP3 determined by qPCR, (b) caspase-1 activity by intracellular FLICA staining, (c) IL-1β and (d) IL-18 of culture supernatant by ELISA from CD4⁺ T cells stimulated under Th17-polarizing conditions and treated with leptin at scalar doses and/or MCC950 or Ac-YVAD-cmk. (e) Representative and (f) cumulative data of flow cytometry results treated as above. (g) IL-17A of culture supernatant determined by ELISA and (h) mRNA level of RORγt by qPCR from CD4⁺ T cells treated as above (n = 10). *P < 0.05, **P < 0.01, ***P < 0.001.