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. 2020 May 27;11:206. doi: 10.1186/s13287-020-01719-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Enhanced therapeutic efficacy of 3D-exos in cisplatin-treated TECs. a TECs took up 2D-exos and 3D-exos. DiI-positive (red) cells were observed under confocal microscope. Scale bar, 10 μm. b DiI-positive cells detecting by flow cytometry. Blue solid peak represents cisplatin-treated TECs internalizing DiI-labeled 2D-exos, and the green solid peak represents cisplatin-treated TECs internalizing DiI-labeled 3D-exos. c The uptake efficiency of 2D-exos and 3D-exos. d Real-time PCR analysis of inflammatory cytokine mRNA levels in TECs (n = 4). e CCK-8 assay in TECs (n = 6). Data are presented as mean ± SD, *p < 0.05, **p < 0.01, ***p < 0.001, vs. Cis group, ^#p < 0.05, ^##p < 0.01, ^###p < 0.001