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. 2020 May 27;39:94. doi: 10.1186/s13046-020-01592-0

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Circ_0008532 promotes BC cell migration, invasion, angiogenesis, and tumor metastasis. a Schematic representation of the sites of the siRNA specific to the back-splice junction of circ_0008532. b The level of circ_0008532 in EJ and T24 cells with stable expression or silencing of circ_0008532. c Representative pictures (left panel) and quantification (right panel) of invaded cells analyzed using a Transwell Matrigel assay. d Representative pictures (left panel) and percentage of the original wound area (right panel) of EJ cells analyzed using a wound-healing assay. e Representative images (left panel) and quantification (right panel) of HUVECs cultured on Matrigel-coated plates with conditioned medium from EJ cells. f Representative image of metastatic lung colonization in nude mice . g Kaplan–Meier curves for nude mice. Bar graphs show the statistical analysis of three independent experiments (* P < 0.05)