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. Author manuscript; available in PMC: 2020 May 27.

Published in final edited form as: Adv Stud Biol. 2009;1(2):61–83.

Table 1:

Top 5 categories that have the most significant difference in gene expression due to aging (24 month vs. 6 month).

male WT			female WT
disorder	Number^a	p value^b	disorder	number^a	p value^b
cancer	202	8.41E-09	metabolism	28	1.24E-06
connective tissue	67	1.70E-06	gastrointestinal	21	1.99E-06
development	54	3.57E-06	cancer	85	2.36E-06
endocrine system	40	3.69E-05	genetic	34	7.50E-05
metabolism	38	4.61E-05	development	21	9.62E-05
male KO			female KO
disorder	number^a	p value^b	disorder	number^a	p value^b
cancer	123	1.77E-09	immulogical	91	2.34E-22
reproductive system	57	2.51E-09	connective tissue	64	4.85E-20
connective tissue	36	2.92E-08	inflammatory	87	4.85E-20
inflammatory	55	2.92E-08	skeletal and muscular	68	4.85E-20
skeletal and muscular	40	2.92E-08	metabolic	49	4.85E-20

^a:

number for genes involved in disorders with at least 2 fold change in mRNA levels.

^b:

statistics significance in comparisons between 24 and 6-month-old mice.