Table 7:
Fold changes of the mRNA levels of cell growth regulation-related genes in aging male mouse liver.
| cell growth-inhibition related genes | Fold change (24 vs. 6 month) | ||
|---|---|---|---|
| Name | Description | WT | RXRα deficiency |
| SMARCB1 | SWI/SNF related,member 1 | 2.62 | (-) |
| BACH2 | basic leucine zipper transcription actor2 | 2.38 | (-) |
| DLEU2 | deleted in lymphocytic leukemia, 2 | 2.28 | (-) |
| RNF6 | ring finger protein (C3H2C3 type) 6 | 2.27 | (-) |
| RASSF5 | Ras association domain family 5 | 2.27 | (-) |
| ING2 | inhibitor of growth family, member 2 | 2.22 | (-) |
| LATS2 | LATS, large tumor suppressor, | 2.02 | (-) |
| SOD1 | superoxide dismutase 1, soluble | 2.01 | (-) |
| CEACAM1 | Carcinoembryonic cell adhesion molecule | −2.05 | (-) |
| EDNRB | endothelin receptor type B | −2.07 | (-) |
| SEL1L | sel-1 suppressor of lin-12-like | −2.08 | (-) |
| LASP1 | LIM and SH3 protein 1 | −2.08 | (-) |
| JDP2 | jun dimerization protein 2 | −2.16 | (-) |
| ID4 | inhibitor of DNA binding 4, | −2.34 | (-) |
| RHOB | ras homolog gene family, member B | −2.72 | (-) |
| FLNA | filamin A, alpha | −2.93 | (-) |
| TAGLN | transgelin | −3.02 | (-) |
| CDKN1A | p21, Cip1 | −4.65 | (-) |
| DUSP6 | dual specificity phosphatase 6 | −4.65 | (-) |
| PLK3 | polo-like kinase 3 (Drosophila) | −5.26 | (-) |
| KLF6 | Kruppel-like factor 6 | −6.9 | (-) |
| DUSP1 | dual specificity phosphatase 1 | −7.41 | (-) |
| EGR2 | early growth response 2 | −7.46 | (-) |
| BTG2 | BTG family, member 2 | −9.35 | (-) |
| EGR1 | early growth response 1 | −13.48 | (-) |
| WEE1 | Wee1 | (-) | 5.23 |
| GPX3 | glutathione peroxidase 3 | (-) | 3.78 |
| SOCS2 | suppressor of cytokine signaling 2 | (-) | 3.02 |
| FHIT | fragile histidine triad gene pleckstrin homology domain interacting | (-) | 2.67 |
| PHIP | protein | (-) | 2.17 |
| DEFB1 | defensin, beta 1 | (-) | 2.02 |
| NFIL3 | nuclear factor, interleukin 3, regulated | (-) | −2.47 |
| SOCS3 | suppressor of cytokine signaling 3 | (-) | −2.91 |
| cell growth-stimulation related genes | Fold change (24 vs. 6 month) | ||
| Name | Description | WT | RXRα deficiency |
| TFAP2A | transcription factor AP-2 alpha | 2.16 | (-) |
| PIM1 | pim-1 oncogene | 2.06 | (-) |
| MDM2 | Mdm2, p53 binding protein (mouse) | −2.05 | (-) |
| TFF3 | trefoil factor 3 (intestinal) | −2.05 | (-) |
| MAP3K14 | mitogen-activated protein 3 kinase 14 | −2.21 | (-) |
| FYN | FYN oncogene | −2.36 | (-) |
| CRKL | v-crk sarcoma virus CT10 oncogene | −2.53 | (-) |
| AXL | AXL receptor tyrosine kinase | −2.65 | (-) |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | −2.67 | (-) |
| SERTAD1 | SERTA domain containing 1 | −2.71 | (-) |
| SPHK1 | sphingosine kinase 1 | −2.79 | (-) |
| PTTG1 | pituitary tumor-transforming 1 | −2.95 | (-) |
| ETS2 | v-ets oncogene | −3.45 | (-) |
| JUNB | jun B proto-oncogene | −3.77 | (-) |
| JUN | jun oncogene | −6.54 | (-) |
| FOS | v-fos oncogene | −7.14 | (-) |
| MYC | v-myc oncogene | −17.07 | (-) |
| CD74 | CD74 | (-) | 2.16 |
| CRIP1 | cysteine-rich protein 1 | (-) | 2.31 |
| PML | promyelocytic leukemia | (-) | 5.38 |
| PROM1 | prominin 1 | (-) | 2.63 |
| RBM3 | RNA binding motif protein 3 | (-) | 3.35 |
| S100A6 | S100 calcium binding protein A6 | (-) | 5.81 |
| SLPI | leukocyte peptidase inhibitor | (-) | 3.39 |