Table 5.
Recommended hypofractionation regimens based on availability/use of concurrent and sequential radiochemotherapy, or radiotherapy alone.
| Would you consider hypofractionated radiotherapy as appropriate? | ||
|---|---|---|
| Case 2 stage III NSCLC | Response | Maximum degree of hypofractionation supported |
| Radiotherapy only |
Yes: 97% (strong consensus) No: 3% |
60 Gy in 15 Fx (33%) [21], [22] |
| 60 Gy in 20 Fx (27%) [23] | ||
| 60–66 Gy in 24–30 Fx (2.2–2.75 Gy/day) (23%) [24] | ||
| 55 Gy in 20 Fx (13%) [25] | ||
| None (3%) | ||
| Sequential radiochemotherapy |
Yes: 97% (strong consensus) No: 3% |
60–66 Gy in 24–30 Fx (2.2–2.75 Gy/day) (27%) [24] |
| 55 Gy in 20 Fx (27%) [25] | ||
| 60 Gy in 15 Fx (23%) [21], [22] | ||
| 60 Gy in 20 Fx (20%) [23] | ||
| None (3%) | ||
| Concomitant radiochemotherapy | Yes: 27% No: 73% (consensus) |
See footnote* |
*Although there was consensus not to recommend hypofractionation, the respondents supportive of hypofractionation (n = 11) were asked which fractionation(s) they would support, with multiple answers allowed. The favored options were 60–66 Gy in 22–30 Fx, given at 2.2–2.75 Gy/day, (75%) and 55 Gy in 20 Fx (63%).