Table 2.
Assessment of clinical status in patients receiving low-dose anakinra (n=7)
| Day 0 | Day 7 | ||
|---|---|---|---|
| Discharged from hospital with resumption of normal activities (1) | 0 | 0 | |
| Discharged from hospital but unable to resume normal activities (2) | 0 | 0 | |
| Hospitalised, not requiring supplemental oxygen (3) | 0 | 0 | |
| Hospitalised, requiring supplemental oxygen (4) | 0 | 1 (14%) | |
| Hospitalised, requiring non-invasive mechanical ventilation, high-flow supplemental oxygen, or both (5) | 7 (100%) | 4 (57%) | |
| PaO2:FiO2 >200 mm Hg | 0 | 0 | |
| PaO2:FiO2 100–200 mm Hg (moderate ARDS) | 6 | 2 | |
| PaO2:FiO2 <100 mm Hg (severe ARDS) | 1 | 2 | |
| Hospitalised, requiring invasive mechanical ventilation (6) | 0 | 2 (29%) | |
| Death (7) | 0 | 0 | |
Data are n (%). Clinical status was graded on a 7-point scale at the time of treatment initiation (day 0) and after 7 days. PaO2=partial pressure of oxygen in arterial blood. FiO2=fractional concentration of oxygen in inspired air. ARDS=acute respiratory distress syndrome.