Table 3.
Hazard Ratios for Outcomes in Well-Controlled and Poorly Controlled BG Cohorts under Cox Adjusted Model and Propensity Score-Matching Model
| Well-Controlled versus Poorly Controlled | Unmatched |
Matchedb |
||||
|---|---|---|---|---|---|---|
| Crude |
Adjusteda |
Adjustedc |
||||
| HR (95% CI) | p Valued | HR (95% CI) | p Valued | HR (95% CI) | p Valued | |
| All-cause mortality | 0.09 (0.03,0.30) | <0.001 | 0.13 (0.04,0.44) | <0.001 | 0.14 (0.03,0.60) | 0.008 |
| Septic shock | – | – | – | – | – | – |
| ARDS | 0.31 (0.19,0.50) | <0.001 | 0.41 (0.25,0.66) | <0.001 | 0.47 (0.27,0.83) | 0.009 |
| DIC | – | – | – | – | – | – |
| Acute kidney injury | 0.19 (0.04,0.80) | 0.024 | 0.22 (0.05,1.03) | 0.055 | 0.12 (0.01,0.96) | 0.046 |
| Acute heart injury | 0.14 (0.05,0.39) | <0.001 | 0.21 (0.07,0.59) | 0.003 | 0.24 (0.08,0.71) | 0.010 |
HR, hazard ratio; CI, confidence interval.
In mixed-effect Cox model, adjusted variables for comparing BG well-controlled and BG poorly controlled cohorts included age, gender, indicators of the severity of COVID-19, and comorbidities (hypertension, coronary heart disease, cerebrovascular diseases, chronic liver diseases, and chronic renal diseases)
In the propensity score-matched model, age, gender, hospital sites, indicators of the severity of COVID-19, comorbidities (hypertension, coronary heart disease, cerebral vascular disease, chronic liver disease, and chronic renal diseases), and incidence of increased creatinine were matched
Mixed-effect Cox model using the hospital site as a random effect and adjusting imbalanced durations from symptom onset to admission
p values were calculated based on Cox proportional hazard model