TABLE 2.

Indications for HSCT balanced with donor availability: Risk/benefit ratio considerations.

Matched sibling donor	Matched unrelated donor or minimally mismatched good quality cord product	Mismatched marrow donor, haploidentical donor
•Stroke •Elevated TCD velocity •Acute chest syndrome •VOC •Pulmonary Hypertension/tricuspid regurgitation jet velocity.2.5 m/s •Osteonecrosis/AVN •Red cell alloimmunization •Silent stroke specially with cognitive impairment •Recurrent priapism •Sickle nephropathy	•Stroke •Elevated TCD velocity •Recurrent acute chest syndrome despite supportive care •Recurrent severe VOC despite supportive care •Red cell alloimmunization despite intervention plus established indication for chronic transfusion therapy •Pulmonary hypertension	•Recurrent stroke despite adequate chronic transfusion therapy •Inability to tolerate supportive care though strongly indicated, e.g., red cell alloimmunization, severe VOC and inability to take hydroxyurea

HSCT, hematopoietic stem cell transplantation; AVN, avascular necrosis; TCD, transcranial doppler; VOC, vaso-occlusive crisis.