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. 2020 May 19;11:425. doi: 10.3389/fphys.2020.00425

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Copyright © 2020 Yang, Wang, Zhang, Cai, Jiang, Zha and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Met increased the expression of PK2/PKR signaling pathway members in DM mice. (A) Immunohistochemical staining for PK2. (B) Immunohistochemical staining for PKR1. (C) Immunohistochemical staining for PKR2. n = 4–5 per group. (D) Expression of PKR1 mRNA, as determined by RT-PCR. (E) Expression of PKR2 mRNA, as determined by RT-PCR. (F) Images of PK2, PKR1, and PKR2 protein levels. (G) Analysis of PK2. (H) Analysis of PKR1. (I) Analysis of PKR2. The data are mean ± SEM; * P value less than 0.05 versus the control group; ^# P value less than 0.05 versus the DM group; n = 4–8 per group.