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Roles and solutions of autophagy in HCC development and sorafenib resistance. The role of autophagy in HCC development and sorafenib resistance remains controversial. Most studies showed that inhibiting autophagy could enhance the effect of sorafenib through multiple pathways. A few research studies have reported that autophagy can induce cell apoptosis and plays a synergistic role with sorafenib.
HCC, hepatocellular carcinoma; 3-MA, 3-methyladenine; mAb, monoclonal antibody.
