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. 2019 Jun 7;116(3):658–670. doi: 10.1093/cvr/cvz148

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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2019. For permissions, please email: journals.permissions@oup.com.

This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)

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MYH6:mCherry⁺ cells display atrial-like, ventricular-like, or nodal-like action potential morphology. (A) Examples of the mean spontaneous action potential recorded using whole-cell patch clamp from each of the three subtypes characterized by upstroke velocity (dV/dt_max) and action potential shape (APD_90/30 ratio). (B) Action potential parameters from all recorded cells (n = 15) separated by subtype. Boxplot whiskers represent maximum and minimum values within 1.5*inter-quartile range. (C) Images of calcium transients of MYH6:mCherry expressing cells. Scale bar: 50 µm. (D) MYH6:mCherry⁺ cells respond to caffeine stimulation. Data represent cells analysed from three independent experiments.