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. 2020 Apr 16;57(1):67–79. doi: 10.3892/ijo.2020.5049

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Functions and clinical significance of circRNAs in glioma. (A) Representative diagram of circRNAs involved in the regulation of glioma cell proliferation, migration, invasion, etc. Multiple identified circRNAs act as miRNA sponges and subsequently upregulate the relevant target gene expression level. These target genes or proteins further regulate downstream factors associated with cancer signaling pathways via acting as transcriptional factors or regulatory proteins and other mechanisms. For example, circ-NFIX activates the Notch signaling pathway through miR-34a-5p. (B) Representative diagram of circRNAs involved in the regulation of glioma cell proliferation, migration, invasion, etc. Multiple identified circRNAs act as miRNA sponges and subsequently downregulate the relevant target gene expression level. These target genes or proteins further regulate downstream factors associated with cancer signaling pathways via acting as transcriptional factors or regulatory proteins and other mechanisms. For example, cir-ITCH activates the Wnt/β-catenin signaling pathway through miR-214. circRNA, circular RNA.

Functions and clinical significance of circRNAs in glioma. (A) Representative diagram of circRNAs involved in the regulation of glioma cell proliferation, migration, invasion, etc. Multiple identified circRNAs act as miRNA sponges and subsequently upregulate the relevant target gene expression level. These target genes or proteins further regulate downstream factors associated with cancer signaling pathways via acting as transcriptional factors or regulatory proteins and other mechanisms. For example, circ-NFIX activates the Notch signaling pathway through miR-34a-5p. (B) Representative diagram of circRNAs involved in the regulation of glioma cell proliferation, migration, invasion, etc. Multiple identified circRNAs act as miRNA sponges and subsequently downregulate the relevant target gene expression level. These target genes or proteins further regulate downstream factors associated with cancer signaling pathways via acting as transcriptional factors or regulatory proteins and other mechanisms. For example, cir-ITCH activates the Wnt/β-catenin signaling pathway through miR-214. circRNA, circular RNA.