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. 2020 Apr 27;57(1):264–276. doi: 10.3892/ijo.2020.5055

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Copyright: © Guo et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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miR-508-3p functions as a tumor suppressor in ovarian cancer. (A) MTT assay results demonstrated that miR-508-3p inhibited the proliferation of HeyA8, SKOV3 and A2780 cells transfected with miR-508-3p or miR-ctrl. (B) Colony formation efficiency of the transfected ovarian cancer cells relative to the miR-ctrl groups. (C) miR-508-3p induced G1 phase arrest in ovarian cancer cells. The percentage of the miR-508-3p- or miR-ctrl-transfected ovarian cancer cells in each phase was assessed by flow cytometry. (D) Representative images and numbers of migratory or invasive cells following transfection with miR-508-3p or miR-ctrl analyzed by Transwell assays. Statistical comparisons were performed using the Wilcoxon test. ^*P<0.05, ^**P<0.01, ^***P<0.001 vs. miR-ctrl. miR, microRNA; ctrl, control.