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. 2020 Apr 27;57(1):264–276. doi: 10.3892/ijo.2020.5055

Figure 5.

Figure 5

miR-508-3p expression in ovarian cancer is lower compared with that in the adjacent non-tumor tissue, and is associated with low CCNA2 and MMP7 expression levels. (A-C) Expression of (A) miR-508-3p, (B) CCNA2 and (C) MMP7 in ovarian cancer and adjacent non-tumor tissue. (D) Representative images of ISH of miR-508-3p and IHC for CCNA2, MMP7 and Ki67 in cases expressing low or high levels of miR-508-3p. (E) Bar charts demonstrating the association between the expression of miR-508-3p and CCNA2, MMP7 and Ki-67 determined by IHC. Student's t-test and log-rank test was used to analyze the data. Patients were stratified into high and low expression subgroups using the mean miR-508-3p, CCNA2 or MMP7 expression scores. **P<0.01, ***P<0.001. miR, microRNA; CCNA2, cyclin A2; MMP7, matrix metalloproteinase 7; ISH, in situ hybridization; IHC, immunohistochemistry.