Figure 5.

VFX stimulates an MMP-9-dependent increase in the power of γ oscillations in ex vivo hippocampal slices from CORT-treated animals. A, B, Results from LFP recordings of carbachol-stimulated low and high γ power in ex vivo hippocampal slices. VFX increases low and high γ power in CORT-treated animals. The difference between CORT and CORT + VFX groups is significant (4-6 mice, n = 11-13 slices, low γ, p = 0.026, high γ, p = 0.016, one-way ANOVA with Tukey's multiple comparisons), as is the difference between control and CORT groups (low γ, p = 0.041, high γ, p = 0.038, one-way ANOVA with Tukey's multiple comparisons). In contrast, the difference between controls and CORT + VFX groups is not significant. C, Representative tracings from the 3 groups as indicated. D, E, There is no significance difference between the CORT and CORT + VFX groups in MMP-9 KO animals (4 or 5 mice, n = 11 or 12 slices, low γ, p = 0.54, high γ, p = 0.49, one-way ANOVA with Tukey's multiple comparisons). F, We show representative tracings from the KO animals. *p < 0.05.