Table 2.
Predictors of OS in patients with MM (n = 3353)
| Variable | HR* | 95% CI* | P |
|---|---|---|---|
| Cytogenetic group | |||
| Neither C1A nor HRCA | Ref | — | |
| HRCA present/no C1A | 1.57 | 1.30-1.91 | <.001 |
| C1A present/no HRCA | 1.42 | 1.19-1.69 | <.001 |
| Both C1A and HRCA present | 1.84 | 1.42-2.38 | <.001 |
| Age, y | 1.03 | 1.02-1.03 | <.001 |
| Male | 1.26 | 1.11-1.44 | <.001 |
| Race/ethnicity | |||
| Non-Hispanic white | Ref | — | |
| Hispanic or Latino | 0.65 | 0.47-0.88 | .006 |
| Non-Hispanic African American | 0.85 | 0.70-1.02 | .084 |
| Other | 0.91 | 0.72-1.15 | .446 |
| Unknown | 1.27 | 1.00-1.61 | .046 |
| M-protein subtype | |||
| IgG | Ref | 1.18-1.63 | <.001 |
| IgA | 1.38 | 1.13-1.58 | .001 |
| Other | 1.33 | 2.04-3.25 | <.001 |
| Unknown | 2.57 | ||
| First-line therapy | |||
| IMiD + PI based | Ref | 0.84-1.24 | .866 |
| IMiD based | 1.02 | 1.25-1.75 | <.001 |
| PI based | 1.48 | 0.90-1.39 | .314 |
| Non-IMiD/PI | 1.12 | ||
| ASCT | 0.33 | 0.26-0.40 | <.001 |
HRCA is defined as presence of 1 of the following: del(17p), t4;14, or t14;16).
Ref, reference.
*
HRs and 95% CIs were derived from a multivariable Cox proportional hazards regression model; all variables in the table were included in the same model simultaneously. The interaction terms between first-line treatment and cytogenetic group as well as ASCT and cytogenetic group were not statistically significant (results not shown).