Table 4.
Multivariable Cox regression model for overall survival limiting cases diagnosed from 2015 or later (n = 2033)
| Variable | HR* | 95% CI* | P |
|---|---|---|---|
| Cytogenetic group | |||
| Neither C1A nor HRCA | Ref | — | .094 |
| HRCA present/no C1A | 1.35 | 0.95-1.92 | .029 |
| C1A present/no HRCA | 1.34 | 1.03-1.75 | <.001 |
| Both C1A and HRCA present | 2.08 | 1.47-2.94 | |
| Age, y | 1.02 | 1.01-1.03 | .006 |
| Male | 1.12 | 0.90-1.38 | .304 |
| Race/ethnicity | |||
| Non-Hispanic white | Ref | — | .132 |
| Hispanic or Latino | 0.67 | 0.40-1.12 | .399 |
| Non-Hispanic African American | 1.14 | 0.84-1.53 | .944 |
| Other | 1.01 | 0.71-1.45 | .281 |
| Unknown | 1.21 | 0.85-1.72 | |
| M-protein subtype | |||
| IgG | Ref | 1.27-2.18 | <.001 |
| IgA | 1.67 | 1.21-2.09 | .001 |
| Other | 1.59 | 1.50-3.22 | <.001 |
| Unknown | 2.20 | ||
| First-line therapy | |||
| IMiD + PI based | Ref | 0.88-1.67 | .239 |
| IMiD based | 1.21 | 1.25-2.09 | <.001 |
| PI based | 1.61 | 0.78-1.92 | .378 |
| Non-IMiD/PI | 1.23 | ||
| ASCT | 0.23 | 0.15-0.35 | <.001 |
HRCA is defined as presence of 1 of the following: del(17p), t4;14, or t14;16).
*
HRs and 95% CIs were derived from a multivariable Cox proportional hazards regression model; all variables in the table were included in the same model simultaneously.