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. 2020 May 26;4(10):2325–2338. doi: 10.1182/bloodadvances.2020001466

Table 5.

Multivariable analysis of OS and LFS for subgroups

Subgroup HR 95% CI P
OS
 CD28 vs 4-1BB 0.609 0.254-1.461 .267
 With vs without EMD 0.455 0.196-1.056 .067
 No previous transplant vs posttransplant relapse 2.184 0.830-5.744 .113
 BM blasts ≤20% vs >20% 2.968 1.270-6.901 .012*
 TP53+ mutation vs TP53 mutation 0.189 0.073-0.488 .001
 CAR T-cell bridged into allo-HSCT vs CAR T-cell therapy alone 12.250 4.774-31.438 <.001
LFS
 CD28 vs 4-1BB 0.927 0.351-2.452 .879
 Without vs with EMD 1.192 0.455-3.123 .720
 No previous transplant vs posttransplant relapse 2.881 0.939-8.837 .064
 BM blasts ≤20% vs >20% 1.569 0.610-4.039 .350
 TP53+ mutation vs TP53 mutation 0.279 0.092-0.849 .025*
 CAR T-cell bridged into allo-HSCT vs CAR T-cell therapy alone 26.430 7.292-95.793 <.001
*

P < .05.

P < .01.